BDBM682573 (R)-1-(4-(4-((1-(3-(difluoromethyl)-2- fluorophenyl)ethyl)amino)quinolin-6- yl)piperazin-1-yl)-2-methylpropan-1-one::US20240208909, Compound 17

SMILES CC(C)C(=O)N1CCN(CC1)c1ccc2nccc(N[C@H](C)c3cccc(C(F)F)c3F)c2c1

InChI Key InChIKey=NSGFLDSUQSTXHJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682573   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682573(US20240208909, Compound 17 | (R)-1-(4-(4-((1-(3-(d...)
Affinity DataIC50: 10nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent