BDBM682574 6-((S)-3-aminopyrrolidin-1-yl)-N-((R)-1-(3- (difluoromethyl)-2-fluorophenyl)ethyl)quinolin- 4-amine::US20240208909, Compound 18

SMILES C[C@@H](Nc1ccnc2ccc(cc12)N1CC[C@H](N)C1)c1cccc(C(F)F)c1F

InChI Key InChIKey=OKDBWWZRFXKZHZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682574   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682574(US20240208909, Compound 18 | 6-((S)-3-aminopyrroli...)
Affinity DataIC50: 55nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent