BDBM682579 (R)-2-methyl-8-(4-((1-(2-methyl-3- (trifluoromethyl)phenyl)ethyl)amino)quinolin-6- yl)-2,8-diazaspiro[4.5]decan-1-one::US20240208909, Compound 23

SMILES C[C@@H](Nc1ccnc2ccc(cc12)N1CCC2(CCN(C)C2=O)CC1)c1cccc(c1C)C(F)(F)F

InChI Key InChIKey=KZDGDDJGYYINRA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682579   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682579(US20240208909, Compound 23 | (R)-2-methyl-8-(4-((1...)
Affinity DataIC50: 55nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent