BDBM682604 (R)-6-(4-aminopiperidin-1-yl)-N-(1-(3- (difluoromethyl)-2-fluorophenyl)ethyl)quinolin- 4-amine::US20240208909, Compound 49

SMILES C[C@@H](Nc1ccnc2ccc(cc12)N1CCC(N)CC1)c1cccc(C(F)F)c1F

InChI Key InChIKey=GYLDNVVDKRKTCV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682604   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682604(US20240208909, Compound 49 | (R)-6-(4-aminopiperid...)
Affinity DataIC50: 10nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent