BDBM682618 (R)-6-(1,4-diazepan-1-yl)-N-(1-(2-methyl-3- (trifluoromethyl)phenyl)ethyl)quinolin-4-amine::US20240208909, Compound 63

SMILES C[C@@H](Nc1ccnc2ccc(cc12)N1CCCNCC1)c1cccc(c1C)C(F)(F)F

InChI Key InChIKey=SOUSLCCNKSXGSN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682618   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682618(US20240208909, Compound 63 | (R)-6-(1,4-diazepan-1...)
Affinity DataIC50: 55nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent