BDBM682622 (R)-N-(1-(2-methyl-3- (trifluoromethyl)phenyl)ethyl)-6-(4,7- diazaspiro[2.5]octan-7-yl)quinolin-4-amine::US20240208909, Compound 69

SMILES C[C@@H](Nc1ccnc2ccc(cc12)N1CCNC2(CC2)C1)c1cccc(c1C)C(F)(F)F

InChI Key InChIKey=WSBIPLQPHUIDQI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682622   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682622(US20240208909, Compound 69 | (R)-N-(1-(2-methyl-3-...)
Affinity DataIC50: 55nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent