BDBM682625 (R)-1-(4-(4-((1-(3-(difluoromethyl)-2- fluorophenyl)ethyl)amino)-7-methoxyquinolin- 6-yl)-4-methoxypiperidin-1-yl)ethan-1-one::US20240208909, Compound 73

SMILES COc1cc2nccc(N[C@H](C)c3cccc(C(F)F)c3F)c2cc1C1(CCN(CC1)C(C)=O)OC

InChI Key InChIKey=PEKBGCPZJAOYAR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 682625   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682625(US20240208909, Compound 73 | (R)-1-(4-(4-((1-(3-(d...)
Affinity DataIC50: 10nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Haihe Biopharma Co.

US Patent
LigandPNGBDBM682625(US20240208909, Compound 73 | (R)-1-(4-(4-((1-(3-(d...)
Affinity DataIC50: 100nMAssay Description:Experimental reagents: KRASG12C/SOS binding kit (Cisbio, cat. 63ADK000CB16PEG); DMSO (Sigma, cat. D8418-1L); and 384-well white plate (PerkinElmer, c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent