BDBM682630 (R)-2-fluoro-1-(4-methoxy-4-(4-((1-(2-methyl-3- (trifluoromethyl)phenyl)ethyl)amino)quinolin-6- yl)piperidin-1-yl)ethan-1-one::US20240208909, Compound 78

SMILES COC1(CCN(CC1)C(=O)CF)c1ccc2nccc(N[C@H](C)c3cccc(c3C)C(F)(F)F)c2c1

InChI Key InChIKey=ZXDINQBLRXYVII-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682630   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682630(US20240208909, Compound 78 | (R)-2-fluoro-1-(4-met...)
Affinity DataIC50: 10nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent