BDBM682632 (R)-1-(4-methoxy-4-(4-((1-(2-methyl-3- (trifluoromethyl)phenyl)ethyl)amino)quinolin-6- yl)piperidin-1-yl)-2-methylpropan-1-one::US20240208909, Compound 80

SMILES COC1(CCN(CC1)C(=O)C(C)C)c1ccc2nccc(N[C@H](C)c3cccc(c3C)C(F)(F)F)c2c1

InChI Key InChIKey=FPXYREXMQIKRSP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682632   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682632(US20240208909, Compound 80 | (R)-1-(4-methoxy-4-(4...)
Affinity DataIC50: 55nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent