BDBM682652 (S)-3-(4-(((R)-1-(3-(difluoromethyl)-2- fluorophenyl)ethyl)amino)quinolin-6-yl)-3- methoxy-N-methylpyrrolidine-1-carboxamide::US20240208909, Compound 102

SMILES CNC(=O)N1CC[C@](C1)(OC)c1ccc2nccc(N[C@H](C)c3cccc(C(F)F)c3F)c2c1

InChI Key InChIKey=KONCCPGIBULZRZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682652   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Accutar Biotechnology

US Patent
LigandPNGBDBM682652(US20240208909, Compound 102 | (S)-3-(4-(((R)-1-(3-...)
Affinity DataIC50: 10nMAssay Description:SOS1 binding affinity of candidate compounds was measured by monitoring the interaction of SOS1 with KRAS-G12D in the presence of the test compound. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent