BDBM682841 2-(2-chlorophenyl)-7- (phthalazin-1-yl)-5,7- diazaspiro[3.4]octane- 6,8-dione::US20240208970, Compound 49
SMILES Clc1ccccc1C1CC2(C1)NC(=O)N(C2=O)c1cncc2ccccc12
InChI Key InChIKey=XQFMLNUPNCXPRN-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 682841
Affinity DataIC50: 2.60nMAssay Description:Inhibition of SARS-CoV-2 MPro using Dabcyl-KTSAVLQSGFRKME-Edans as substrate measured after 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataKd: 38nMAssay Description:Binding affinity to SARS-CoV-2 Main protease assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:It was performed in 20 mM Tris, 50 mM NaCl and 0.1 mM EDTA (Merck KGaA, Darmstadt, Germany), pH 7.5 at room temperature. Compounds were transferred w...More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of SARS-CoV-2 Main protease assessed as hydrolysis of quenched fluorogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of SARS CoV-2 main protease extracted from Escherichia coli BL21 (DE3) T1R competent cells using DABCYL-Lys-HCoV-SARS Replicase Polyprotei...More data for this Ligand-Target Pair