BDBM682990 1-[(2S,5S)-8-chloro-2,3- dihydro-2,5-methano-1,4- benzoxazepin-4(5H)-yl]- 3,3-difluoro-2,2- dimethylpropan-1-one::US20240208986, Compound 2-21

SMILES CC(C)(C(F)F)C(=O)N1C[C@@H]2C[C@H]1c1ccc(Cl)cc1O2

InChI Key InChIKey=ZZUVPROUSGLZTR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682990   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM682990(US20240208986, Compound 2-21 | 1-[(2S,5S)-8-chloro...)
Affinity DataIC50: 37nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
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Date in BDB:
10/4/2024
Entry Details
US Patent