BDBM682993 1-[(2S,5S)-9-chloro-7- fluoro-2,3-dihydro-2,5- methano-1,4- benzoxazepin-4(5H)-yl]- 3,3-difluoro-2,2- dimethylpropan-1-one::US20240208986, Compound 2-24

SMILES CC(C)(C(F)F)C(=O)N1C[C@@H]2C[C@H]1c1cc(F)cc(Cl)c1O2

InChI Key InChIKey=RDKBNKFBTBCHRN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682993   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM682993(US20240208986, Compound 2-24 | 1-[(2S,5S)-9-chloro...)
Affinity DataIC50: 30nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
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Date in BDB:
10/4/2024
Entry Details
US Patent