BDBM682994 (2S,5S)-7-fluoro-4-(4- fluorobicyclo[2.2.1]heptane- 1-carbonyl)-2,3,4,5- tetrahydro-2,5-methano- 1,4-benzoxazepine-9- carbonitrile::US20240208986, Compound 2-25

SMILES Fc1cc(C#N)c2O[C@H]3C[C@H](N(C3)C(=O)C34CCC(F)(CC3)C4)c2c1

InChI Key InChIKey=FPOXLURCQBNYCZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 682994   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM682994(US20240208986, Compound 2-25 | (2S,5S)-7-fluoro-4-...)
Affinity DataIC50: 10nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent