BDBM683118 Preparation of 2-(4-aminopiperidin-1-yl)-4-(4-cyano-3-fluorophenyl)-5-(3-hydroxy-4-methoxyphenyl)nicotinon itrile hydrochloride::US20240216357, Example 66

SMILES COc1ccc(cc1O)-c1cnc(N2CCC(N)CC2)c(C#N)c1-c1ccc(C#N)c(F)c1

InChI Key InChIKey=UDNGFZACHQCXTP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 683118   

TargetLysine-specific histone demethylase 1A(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM683118(US20240216357, Example 66 | Preparation of 2-(4-am...)
Affinity DataIC50: 0.200nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM683118(US20240216357, Example 66 | Preparation of 2-(4-am...)
Affinity DataIC50: 3.65E+3nMAssay Description:Using mixed human liver microsomes as a CYP 450 enzyme source, specific probe substrates of respective CYP isoenzymes (2 substrates for CYP 3A4) are ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM683118(US20240216357, Example 66 | Preparation of 2-(4-am...)
Affinity DataIC50: 1.55E+4nMAssay Description:A manual patch-clamp technology is used to evaluate whether the test compound has a potential inhibitory effect on a voltage-gated potassium ion chan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent