BDBM683122 2-(4-aminopiperidin-1- yl)-4-(4-cyano- 3-fluoro phenyl)-5-(3- hydroxy-4- (trifluoromethyl) phenyl) nicotinonitrile hydrochloride::US20240216357, Example 70

SMILES NC1CCN(CC1)c1ncc(-c2ccc(c(O)c2)C(F)(F)F)c(-c2ccc(C#N)c(F)c2)c1C#N

InChI Key InChIKey=WHISBWLMTWUMKY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 683122   

TargetLysine-specific histone demethylase 1A(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM683122(US20240216357, Example 70 | 2-(4-aminopiperidin-1-...)
Affinity DataIC50: 0.5nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM683122(US20240216357, Example 70 | 2-(4-aminopiperidin-1-...)
Affinity DataIC50: 8.71E+3nMAssay Description:Using mixed human liver microsomes as a CYP 450 enzyme source, specific probe substrates of respective CYP isoenzymes (2 substrates for CYP 3A4) are ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent