BDBM683774 4-(2-{[(4aS,7aR)-1- methyl-octahydro-1H- cyclopenta[b]pyridin- 4a-yl]methoxy}-4- [(1S,6R)-3,9- diazabicyclo[4.2.1]nonan- 3-yl]-8- fluoroquinazolin-7-yl)- 5-ethylnaphthalen-2-ol::US20240217982, Example 9-3

SMILES CCc1cccc2cc(O)cc(-c3ccc4c(nc(OC[C@]56CCC[C@H]5N(C)CCC6)nc4c3F)N3CC[C@H]4CC[C@@H](C3)N4)c12

InChI Key InChIKey=MDUVJKBSRDWOKX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683774   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683774(US20240217982, Example 9-3 | 4-(2-{[(4aS,7aR)-1- m...)
Affinity DataIC50: 50nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent