BDBM683777 6-{6-chloro- 4-[(1S,6R)- 3,9- diazabicyclo [4.2.1]nonan- 3-yl]-8- fluoro-2- {[1-({3-oxa- 8- azabicyclo [3.2.1]octan- 8- yl}methyl) cyclopropyl] methoxy} quinazolin-7- yl}-4- methyl-5- (trifluorometh-::US20240217982, Example 10-2

SMILES Cc1cc(N)nc(-c2c(Cl)cc3c(nc(OCC4(CN5C6CCC5COC6)CC4)nc3c2F)N2CC[C@H]3CC[C@@H](C2)N3)c1C(F)(F)F

InChI Key InChIKey=VSMDFJSPZUAHTO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683777   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683777(US20240217982, Example 10-2 | 6-{6-chloro- 4-[(1S,...)
Affinity DataIC50: 6nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
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Date in BDB:
10/11/2024
Entry Details
US Patent