BDBM684644 Preparation of 7′-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-1′-(4-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzyl)spiro[cyclobutane-1,4′-pyrimido[4,5-d][1,3]oxazin]-2′(1′H)-one ::US20240226107, Compound 55

SMILES COc1ncnc(C2CC2)c1-c1ncc2c(n1)N(Cc1ccc(cc1)-n1nc(cc1C)C(F)(F)F)C(=O)OC21CCC1

InChI Key InChIKey=VSNLFNTYRBAALB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 684644   

TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Simcere Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM684644(US20240226107, Compound 55 | Preparation of 7̸...)
Affinity DataIC50: 8.70nMAssay Description:Each compound to be tested was dissolved with DMSO to 10 mM. The compound and pure DMSO (with a total volume of 50 nL) were loaded to each well of th...More data for this Ligand-Target Pair
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Date in BDB:
10/22/2024
Entry Details
US Patent