BDBM684647 Preparation of 7-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-4-ethynyl-1-(3-fluoro-4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-4-methyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-one ::US20240226107, Compound 59

SMILES COc1ncnc(C2CC2)c1-c1ncc2c(n1)N(Cc1ccc(-c3nc(cn3C)C(F)(F)F)c(F)c1)C(=O)OC2(C)C#C

InChI Key InChIKey=ZCLDSJPPKUAIIW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 684647   

TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Simcere Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM684647(US20240226107, Compound 59 | Preparation of 7-(4-c...)
Affinity DataIC50: 13.5nMAssay Description:Each compound to be tested was dissolved with DMSO to 10 mM. The compound and pure DMSO (with a total volume of 50 nL) were loaded to each well of th...More data for this Ligand-Target Pair
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Date in BDB:
10/22/2024
Entry Details
US Patent