BDBM684654 Preparation of 2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-5-methyl-8-(3,5-difluoro-4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-7,8-dihydropteridin-6(5H)-one ::US20240226107, Compound 66

SMILES COc1ncnc(C2CC2)c1-c1ncc2c(n1)N(Cc1cc(F)c(-c3nc(C(F)(F)F)cn3C)c(F)c1)CC(=O)N2C

InChI Key InChIKey=ZCCJTFGBWALTRM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 684654   

TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Simcere Zaiming Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 684654BDBM684654(US20240226107, Compound 66 | Preparation of 2-(4-c...)
Affinity DataIC50: 27.2nMAssay Description:Each compound to be tested was dissolved with DMSO to 10 mM. The compound and pure DMSO (with a total volume of 50 nL) were loaded to each well of th...More data for this Ligand-Target Pair
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Date in BDB:
10/22/2024
Entry Details
US Patent