BDBM684835 4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro-2-(((6S,8aS)-hexahydro-1H- pyrrolo[2,1-c][1,4]oxazin-6-yl)methoxy)- 9,10-dihydro-8H-7-oxa-1,3,6,10- tetraazacyclohepta[de]naphthalen-5-yl)- 5-ethynylnaphthalen-2-ol::US20240228512, Example 17

SMILES C[C@@H](N1CCOc2nc(c(F)c3nc(OC[C@@H]4CC[C@H]5COCCN45)nc1c23)-c1cc(O)cc2cccc(C#C)c12)c1cccnc1N

InChI Key InChIKey=RDOLTVNBMWRTOP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684835   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684835(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0800nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684835(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.159nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent