BDBM684846 4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro-2-(((2R,7aS)-2-fluorotetrahydro- 1H-pyrrolizin-7a(5H)-yl)methoxy)-9,10- dihydro-8H-7-oxa-1,3,6,10- tetraazacyclohepta[de]naphthalen-5-yl)- 5-ethylnaphthalen-2-ol::US20240228512, Example 27

SMILES CCc1cccc2cc(O)cc(-c3nc4OCCN([C@H](C)c5cccnc5N)c5nc(OC[C@@]67CCCN6C[C@H](F)C7)nc(c3F)c45)c12

InChI Key InChIKey=UPKOVZHSZRXVOX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684846   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684846(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0400nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684846(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.130nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent