BDBM684851 3-((R)-1-(5-(3-Amino-8- ethynylnaphthalen-1-yl)-4-fluoro-2- (((2R,7aS)-2-fluorotetrahydro-1H- pyrrolizin-7a(5H)-yl)methoxy)-8,9- dihydro-10H-7-oxa-1,3,6,10- tetraazacyclohepta[de]naphthalen-10- yl)ethyl)pyrazin-2-amine::US20240228512, Example 29

SMILES C[C@@H](N1CCOc2nc(c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc1c23)-c1cc(N)cc2cccc(C#C)c12)c1nccnc1N

InChI Key InChIKey=OAZSWQWBYPWQRS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684851   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684851(3-((R)-1-(5-(3-Amino-8- ethynylnaphthalen-1-yl)-4-...)
Affinity DataIC50: 0.0900nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684851(3-((R)-1-(5-(3-Amino-8- ethynylnaphthalen-1-yl)-4-...)
Affinity DataIC50: 0.150nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent