BDBM684857 6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-4-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-9,10-dihydro-8H-7-oxa-1,3,6,10-tetraazacyclohepta[de]naphthalen-5-yl)-3-fluoro-4-methyl-5-(trifluoromethyl)pyridin-2-amine::US20240228512, Example 604

SMILES C[C@@H](N1CCOc2nc(c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc1c23)-c1nc(N)c(F)c(C)c1C(F)(F)F)c1cccnc1N

InChI Key InChIKey=PWERJZOIYRPQMD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684857   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684857(6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-4-fluoro-...)
Affinity DataIC50: 0.0990nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684857(6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-4-fluoro-...)
Affinity DataIC50: 0.225nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent