BDBM684889 6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-2-(((1R,7a'S)-2,2-difluorodihydro-1′H,3′H-spiro[cyclopropane-1,2′-pyrrolizin]-7a′(5′H)-yl)methoxy)-4-fluoro-9,10-dihydro-8H-cyclohepta[de]naphthalen-5-yl)-3-fluoro-4-methyl-5-(trifluoromethyl)pyridin-2-amine::US20240228512, Example 614

SMILES C[C@@H](N1CCOc2nc(c(F)c3nc(OC[C@@]45CCCN4C[C@]4(CC4(F)F)C5)nc1c23)-c1nc(N)c(F)c(C)c1C(F)(F)F)c1cccnc1N

InChI Key InChIKey=JUYAVJIWXQNRMM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684889   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684889(6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-2-(((1R,7...)
Affinity DataIC50: 0.120nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684889(6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-2-(((1R,7...)
Affinity DataIC50: 0.160nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent