BDBM684918 2-(endo-3- amino-8- azabicyclo [3.2.1]octan- 8-yl)-5-(7- chloro-2- methylbenzo [d]thiazol- 6-yl)-3- methyl-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri- midin-4-one::US12037345, Example 7

SMILES Cc1nc2ccc(-c3c[nH]c4nc(N5[C@H]6CC[C@@H]5C[C@H](N)C6)n(C)c(=O)c34)c(Cl)c2s1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 684918   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM684918(US12037345, Example 7 | 2-(endo-3- amino-8- azabic...)
Affinity DataIC50: 9nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent