BDBM684940 2-(3,9- diaza- bicyclo [3.3.1] nonan- 9-yl)-5-(4- chloro-2- methyl-2H- indazol- 5-yl)-3- methyl-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri- midin-4- one::US12037345, Example 27

SMILES Cn1cc2c(Cl)c(ccc2n1)-c1c[nH]c2nc(N3C4CCCC3CNC4)n(C)c(=O)c12

InChI Key InChIKey=OYWYQZPVKYHOJB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 684940   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM684940(US12037345, Example 27 | 2-(3,9- diaza- bicyclo [3...)
Affinity DataIC50: 7nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent