BDBM684973 2-((3S,4S)- 4-amino- 3-methyl- 2-oxa-8- azaspiro [4.5]decan- 8-yl)-5-(4- chloro-2- methyl-2H- indazol- 5-yl)-3- methyl-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri- midin-4- one::US12037345, Example 59

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]cc(-c4ccc5nn(C)cc5c4Cl)c3c(=O)n2C)[C@@H]1N

InChI Key InChIKey=SDSJZLCDKQWGEZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 684973   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM684973(US12037345, Example 59 | 2-((3S,4S)- 4-amino- 3-me...)
Affinity DataIC50: 5.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent