BDBM684980 2-(3,9- diaza- bicyclo [3.3.1] nonan-9- yl)-5-(4- chloro-2- ethyl-2H- indazol- 5-yl)-3- methyl-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri- midin-4- one::US12037345, Example 66

SMILES CCn1cc2c(Cl)c(ccc2n1)-c1c[nH]c2nc(N3C4CCCC3CNC4)n(C)c(=O)c12

InChI Key InChIKey=QZXFDKNQBRLRIE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 684980   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM684980(US12037345, Example 66 | 2-(3,9- diaza- bicyclo [3...)
Affinity DataIC50: 8.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent