BDBM684993 2-(endo- 3-amino- 3-methyl- 8-aza- bicyclo [3.2.1] octan-8- yl)-5-(3,4- dichloro- 2-methyl- 2H- indazol- 5-yl)-3- methyl-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri-::US12037345, Example 79

SMILES Cn1nc2ccc(-c3c[nH]c4nc(N5[C@H]6CC[C@@H]5C[C@](C)(N)C6)n(C)c(=O)c34)c(Cl)c2c1Cl

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 684993   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM684993(US12037345, Example 79 | 2-(endo- 3-amino- 3-methy...)
Affinity DataIC50: 5.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent