BDBM685012 5-(4- chloro-2- methyl-2H- indazol- 5-yl)-3- methyl-2- ((1R,2R, 4S)-2- (methyl- amino)- 7-aza- bicyclo [2.2.1] heptan-7- yl)-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri-::US12037345, Example 97

SMILES CN[C@@H]1C[C@@H]2CC[C@H]1N2c1nc2[nH]cc(-c3ccc4nn(C)cc4c3Cl)c2c(=O)n1C

InChI Key InChIKey=HXBKRBRDSSJXLT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685012   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685012(US12037345, Example 97 | 5-(4- chloro-2- methyl-2H...)
Affinity DataIC50: 7.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent