BDBM685014 2-(3,9- diaza- bicyclo [3.3.1] nonan-9- yl)-5-(3,4- dichloro- 2-methyl- 2H- indazol- 5-yl)-3- methyl-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri- midin-4-one::US12037345, Example 99

SMILES Cn1nc2ccc(-c3c[nH]c4nc(N5C6CCCC5CNC6)n(C)c(=O)c34)c(Cl)c2c1Cl

InChI Key InChIKey=CSQBWVCDZHOCHK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685014   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685014(US12037345, Example 99 | 2-(3,9- diaza- bicyclo [3...)
Affinity DataIC50: 4.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2024
Entry Details
US Patent