BDBM685018 2-((1R, 2R,4S)- 2-amino- 7-aza- bicyclo [2.2.1] heptan-7- yl)-5-(3,4- dichloro- 2-(fluoro- methyl)- 2H- indazol- 5-yl)-3- methyl-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri-::US12037345, Example 103

SMILES Cn1c(nc2[nH]cc(-c3ccc4nn(CF)c(Cl)c4c3Cl)c2c1=O)N1[C@H]2CC[C@@H]1[C@H](N)C2

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685018   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685018(US12037345, Example 103 | 2-((1R, 2R,4S)- 2-amino-...)
Affinity DataIC50: 2nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent