BDBM685051 US12037345, Example 133::rac-2- ((1S,4S, 7S)-7- amino- 2-aza- bicyclo [2.2.1] heptan-2- yl)-5-(4- chloro-2- ethyl-2H- indazol- 5-yl)-3- methyl-3,7- dihydro- 4H-pyrrolo [2,3-d]pyri- midin-4-one

SMILES CCn1cc2c(Cl)c(-c3c[nH]c4nc(N5C[C@@H]6CC[C@H]5[C@H]6N)n(C)c(=O)c34)ccc2n1

InChI Key InChIKey=KCTMQZJLFCWLIL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685051   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 685051BDBM685051(US12037345, Example 133 | rac-2- ((1S,4S, 7S)-7- a...)
Affinity DataIC50: 6.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent