BDBM685052 US12037345, Example 134::rac-((1S, 4S,7S)- 7-amino- 2-aza- bicyclo [2.2.1] heptan-2- yl)-3-(7- chloro- benzo[d] thiazol- 6-yl)-5- methyl-1,5- dihydro- 4H- pyrazolo [3,4-d]pyri- midin-4-one

SMILES Cn1c(nc2[nH]nc(-c3ccc4ncsc4c3Cl)c2c1=O)N1C[C@@H]2CC[C@H]1[C@H]2N

InChI Key InChIKey=TXFVOBDLKWAAKV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685052   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685052(US12037345, Example 134 | rac-((1S, 4S,7S)- 7-amin...)
Affinity DataIC50: 4nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent