BDBM685074 US12037345, Example 155::US12037345, Example 156::rel-2-((1R,4R,7R)-7-amino-2-azabicyclo[2.2.1]heptan-2-yl)-5-(4-chloro-2-ethyl-2H-indazol-5-yl)-3-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (Example 155) and rel-2-((1S,4S,7S)-7-Amino-2-azabicyclo[2.2.1]heptan-2-yl)-5-(4-chloro-2-ethyl-2H-indazol-5-yl)-3-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (Example 156)

SMILES CCn1cc2c(Cl)c(-c3c[nH]c4nc(N5C[C@H]6CC[C@@H]5[C@@H]6N)n(C)c(=O)c34)ccc2n1

InChI Key InChIKey=KCTMQZJLFCWLIL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 685074   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 685074BDBM685074(US12037345, Example 156 | rel-2-((1R,4R,7R)-7-amin...)
Affinity DataIC50: 4nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 685074BDBM685074(US12037345, Example 156 | rel-2-((1R,4R,7R)-7-amin...)
Affinity DataIC50: 250nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2024
Entry Details
US Patent