BDBM685087 2-((1R,2S,4S)-2- amino-7-aza- bicyclo[2.2.1] heptan-7-yl)-3- methyl-5- (3,4,7-trichloro- 2-methyl-2H- indazol-5-yl)- 3,7-dihydro-4H- pyrrolo[2,3-d] pyrimidin-4-one::US12037345, Example 168

SMILES Cn1nc2c(Cl)cc(-c3c[nH]c4nc(N5[C@H]6CC[C@@H]5[C@@H](N)C6)n(C)c(=O)c34)c(Cl)c2c1Cl

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685087   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685087(US12037345, Example 168 | 2-((1R,2S,4S)-2- amino-7...)
Affinity DataIC50: 7nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent