BDBM685088 2-((1R,2R,4S)-2- amino-7-aza- bicyclo[2.2.1] heptan-7-yl)-5- (5-chloro-3- methoxy- quinoxalin-6- yl)-3-methyl- 3,7-dihydro-4H- pyrrolo[2,3-d] pyrimidin-4-one::US12037345, Example 169

SMILES COc1cnc2ccc(-c3c[nH]c4nc(N5[C@H]6CC[C@@H]5[C@H](N)C6)n(C)c(=O)c34)c(Cl)c2n1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685088   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685088(US12037345, Example 169 | 2-((1R,2R,4S)-2- amino-7...)
Affinity DataIC50: 3.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2024
Entry Details
US Patent