BDBM685090 6-((1R,4R,7R)- 7-amino-2-aza- bicyclo[2.2.1] heptan-2-yl)-3- (3,4-dichloro- 2-methyl-2H- indazol-5-yl)- 5-methyl-1,5- dihydro-4H- pyrazolo[3,4-d] pyrimidin-4-one::US12037345, Example 171

SMILES Cn1nc2ccc(-c3n[nH]c4nc(N5C[C@H]6CC[C@@H]5[C@@H]6N)n(C)c(=O)c34)c(Cl)c2c1Cl

InChI Key InChIKey=BZTUAZFECBVRQF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685090   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685090(US12037345, Example 171 | 6-((1R,4R,7R)- 7-amino-2...)
Affinity DataIC50: 2.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent