BDBM685097 2-((1R,2R,4S)- 2-amino-7-aza- bicyclo[2.2.1] heptan-7-yl)-5- (4-chloro-2-(2- methoxyethyl)- 2H-indazol-5- yl)-3-methyl- 3,7-dihydro-4H- pyrrolo[2,3-d] pyrimidin-4-one::US12037345, Example 178

SMILES COCCn1cc2c(Cl)c(ccc2n1)-c1c[nH]c2nc(N3[C@H]4CC[C@@H]3[C@H](N)C4)n(C)c(=O)c12

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685097   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685097(US12037345, Example 178 | 2-((1R,2R,4S)- 2-amino-7...)
Affinity DataIC50: 5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent