BDBM685298 4-(6-chloro-2-((1- ((dimethylami- no)methyl)cyclopro- pyl)methoxy)- 8-fluoro-4-((1S,4S)- 4-methyl-2,5-diaza- bicyclo[2.2.2]octan- 2-yl)quinazolin-7- yl)naphthalen-2-ol::US20240239788, Example 38a

SMILES CN(C)CC1(COc2nc(N3C[C@@]4(C)CC[C@H]3CN4)c3cc(Cl)c(c(F)c3n2)-c2cc(O)cc3ccccc23)CC1

InChI Key InChIKey=CKBURMOTKVQOKC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685298   

LigandPNGBDBM685298(US20240239788, Example 38a | 4-(6-chloro-2-((1- ((...)
Affinity DataIC50: 617nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
US Patent