BDBM685447 6,8-difluoro-2-((1-(((R)-3-fluoropyrrolidin- 1-yl)methyl)cyclopropyl)methoxy)-4- ((1S,5R)-1-methyl-3,8-diazabicyclo [3.2.1]octan-3-yl)-7-(3,5,6-trimethyl-1H- indazol-4-yl)quinazoline::US20240239788, Example 85
SMILES Cc1n[nH]c2cc(C)c(C)c(-c3c(F)cc4c(nc(OCC5(CN6CC[C@@H](F)C6)CC5)nc4c3F)N3C[C@H]4CC[C@](C)(C3)N4)c12
InChI Key InChIKey=VKVFPTTXTOOEJS-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 685447
TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 1.89E+4nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair
