BDBM686482 Rac-3-(1-oxo-5-(((cis)-2-(3-(4- (trifluoromethoxy)phenyl)azetidin- 1-yl)cyclohexyl)oxy)isoindolin-2- yl)piperidine-2,6-dione::US20240246935, Example 61

SMILES FC(F)(F)Oc1ccc(cc1)C1CN(C1)[C@H]1CCCC[C@H]1Oc1ccc2C(=O)N(Cc2c1)C1CCC(=O)NC1=O

InChI Key InChIKey=KACCHMVEEUHVIP-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 686482   

TargetProtein cereblon(Human)
Plexium, Inc.

US Patent
LigandPNGBDBM686482(US20240246935, Example 61 | Rac-3-(1-oxo-5-(((cis)...)
Affinity DataEC50:  14nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent