BDBM6875 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3k::4-({5-amino-1-[(2,6-difluorophenyl)methyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-{[5-amino-1-(2,6-difluorobenzyl)-1H-1,2,4-triazol-3-yl]amino}benzenesulfonamide::US12110278, Compound 2

SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1Cc1c(F)cccc1F

InChI Key InChIKey=YWEKAQYXDFMHKY-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 6875   

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM6875(4-({5-amino-1-[(2,6-difluorophenyl)methyl]-1H-1,2,...)
Affinity DataKd:  1.67E+4nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM6875(4-({5-amino-1-[(2,6-difluorophenyl)methyl]-1H-1,2,...)
Affinity DataKd:  1.67E+4nMAssay Description:Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6875(4-({5-amino-1-[(2,6-difluorophenyl)methyl]-1H-1,2,...)
Affinity DataIC50: 1.00E+5nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed