BDBM687772 Synthesis of 1-Methyl-6-(1H-pyrazol-4-yl)-N-{[3-(trifluoromethyl)phenyl]methyl}pyrrolo[2,3-b]pyridine-2-carboxamide ::US20240246972, Compound 13

SMILES Cn1c(C(=O)NCc2cccc(C(F)(F)F)c2)cc2ccc(-c3cn[nH]c3)nc21

InChI Key InChIKey=ISSFTGHILCIBNN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 687772   

TargetRho-associated protein kinase 2(Human)
Avicenna Biosciences, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 687772BDBM687772(US20240246972, Compound 13 | Synthesis of 1-Methyl...)
Affinity DataIC50: 53.3nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Avicenna Biosciences, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 687772BDBM687772(US20240246972, Compound 13 | Synthesis of 1-Methyl...)
Affinity DataIC50: 414nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent