BDBM687931 1-acetyl-4-[4-({(1R)-1-[3-(1,1-difluoro-2-hydroxyethyl)-2-fluorophenyl]ethyl}amino)-2-methylpyrido[3,4-d]pyrimidin-6-yl]-1,4lambda-azaphosphinan-4-one::US20240247015, Example 42

SMILES C[C@@H](Nc1nc(C)nc2cnc(cc12)P1(=O)CCN(CC1)C(C)=O)c1cccc(c1F)C(F)(F)CO

InChI Key InChIKey=CMWBDVHQODZYND-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 687931   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM687931(US20240247015, Example 42 | 1-acetyl-4-[4-({(1R)-1...)
Affinity DataIC50: 4.87nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
11/7/2024
Entry Details
US Patent