BDBM687954 US20240247015, Example 65::US20240247015, Example 89

SMILES CCC(O)C(F)(F)c1cccc([C@@H](C)Nc2nc(C)nc3cnc(cc23)P(C)(C)=O)c1F

InChI Key InChIKey=IEYKRMXGGDMMKA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 687954   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM687954(US20240247015, Example 89 | US20240247015, Example...)
Affinity DataIC50: 6.06nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM687954(US20240247015, Example 89 | US20240247015, Example...)
Affinity DataIC50: 10.5nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent