BDBM688678 (R)-6-chloro-7-(2-fluorophenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-4-(methyl(1-(oxirane-2-carbonyl)azetidin-3-yl)amino)pyrido[2,3-d]pyrimidin-2(1H)-one::US20240190862, Example 30

SMILES CC(C)c1nccc(C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N(C)C1CN(C1)C(=O)[C@H]1CO1)-c1ccccc1F

InChI Key InChIKey=NGAWGYKFZKABRO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 688678   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM688678(US20240190862, Example 30 | (R)-6-chloro-7-(2-fluo...)
Affinity DataIC50: 3.13E+4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetGTPase KRas [1-169,G12D](Human)
Amgen

US Patent
LigandPNGBDBM688678(US20240190862, Example 30 | (R)-6-chloro-7-(2-fluo...)
Affinity DataIC50: 2.50E+5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM688678(US20240190862, Example 30 | (R)-6-chloro-7-(2-fluo...)
Affinity DataIC50: 2.50E+5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent