BDBM688762 (13R)-3-cyclopropyl-13-(difluoromethyl)-9-(2,6-difluorophenyl)-16-thia-2,4,5,8-tetrazatetracyclo [8.6.0.02,6.011,15]hexadeca-1(10),3,5,8,11(15)-pentaene::US20240190889, Example 7

SMILES FC(F)[C@H]1Cc2sc-3c(c2C1)C(=NCc1nnc(C2CC2)n-31)c1c(F)cccc1F

InChI Key InChIKey=RAKFVWDVZYUQCI-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 688762   

LigandPNGBDBM688762(US20240190889, Example 7 | (13R)-3-cyclopropyl-13-...)
Affinity DataKi:  2.10nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688762(US20240190889, Example 7 | (13R)-3-cyclopropyl-13-...)
Affinity DataKi:  6.40nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688762(US20240190889, Example 7 | (13R)-3-cyclopropyl-13-...)
Affinity DataKi:  304nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent